LOKISNOW is a series of pain reliever product based on "Gate Control Theory" of Ronld Melzack & Patrick Wall. LOKISNOW could help people manage their discomfort by inhibiting pain signal. 

The LOKISNOW series products all contain effective ingredients such as menthol, centella asiatica extract, Paraguay tea extract, Polygonum cuspidatum root extract, and licorice root extract, which are suitable for relieving sedentary fatigue and discomfort caused by exercise. 

LOKISNOW series products involve: reliving gel, relieving spray and relieving roll-on. 

What is “Gate Control Theory”? 

Traditional thinking is that the pain-relieving mechanism of action of menthol, an ingredient in LOKISNOW Pain Reliever Products, results from a counterirritant effect. Simply put, a counter-irritant has an effect of overriding noxious pain signals traveling to the brain through a process modulated between pain-transmitting and non-pain transmitting neurons. This process, known as "gate control" or "gating" , was first described by Melzack and Wall. 

Gate control theory is based on the understanding that pain is transmitted by two kinds of afferent nerve fibers. One is the larger myelinated A-delta fiber, which carries quick, intense-pain messages. The other is the smaller, unmyelinated "C" fiber, which transmits throbbing, chronic pain. A third type of nerve fiber, called A-beta, is "nonnociceptive", meaning it does not transmit pain stimuli. The gate control theory asserts that signals transmitted by the A-delta and C pain fibers can be thwarted by the activation/stimulation of the nonnociceptive A-beta fibers and thus inhibit an individual's perception of pain. 

More recently, researchers have discovered that menthol further stimulates the TRPM8 cold receptors. Even though it has long been accepted that cooling and cold can induce analgesia, the mechanism has been poorly understood. Now, as scientists have continued to isolate these specific heat-sensitive transient receptor potential (TRP) channels within our sensory neurons we are now able to have a much better understanding of the body's cutaneous temperature detection. With the isolation and  further study of these specific TRPM8 receptors there is stronger evidence supporting the benefits achieved with the cooling effect of menthol in functioning as a topical analgesic while activating these receptors and the resulting consequent pain relief.

Advantages of LOKISNOW 

Ice is the time-honored means of effectively delivering cryotherapy, but ice does have disadvantages. It can cause muscle stiffness, skin irritation, temporary pain and numbness, and it generally requires the patient to remain stationary. 

LOKISNOW Pain Reliever products has been shown to be as effective as ice without the disadvantages. Like ice, LOKISNOW Pain Reliever products reduces pain and inflammation. 

By testing of authoritative institutions, the analgesic effect of the entire series of products of LOKISNOW is as high as 99%, with significant analgesic effects.